Huili Guo graduated from the University of Cambridge in 2005 with a B.A. degree in Natural Sciences. In 2011, she received the Ph.D. degree in Biology from the Massachusetts Institute of Technology. She performed her thesis research in the laboratory of Prof. David Bartel at the Whitehead Institute for Biomedical Research, where she used ribosome profiling and RNA-Seq to study the molecular consequences of microRNA-mediated repression in mammalian systems. This work was published in Nature in 2010. This highly-cited piece of work is recommended by the Faculty of 1000, which identifies the most significant articles in biomedical research publications. Huili is a recipient of National Science Scholarships from the Agency for Science, Technology and Research (A*STAR) in 2002 (BS) and 2006 (PhD). She was an Adjunct Assistant Professor with the Department of Biological Sciences, National University of Singapore. Huili was an Ambassador for the STEM (Science, Technology, Engineering and Mathematics) programme run by the Singapore Committee for UN Women. She is a recipient of the L’Oréal Singapore For Women In Science National Fellowship (2014) and the Young Scientist Award (2016). She was an Independent Fellow at IMCB from 2012-2021.