"Dr. Guo’s lab investigates how the control of translation impacts human health and disease. Translation, the process by which information encoded in messenger RNAs is turned into functional proteins, is carried out by cellular machines known as ribosomes. This is a very basic mechanism that impacts multiple processes in the cell. Dr. Guo uses a range of molecular biology and genomics techniques, including ribosome profiling, to probe areas of the translation field that have hitherto been neglected, in order to gain new molecular insights and identify novel therapeutic approaches."